Session 1: Birth of Proteins Focusing on translation mechanisms and the latest research on ribosomes.
Venue: Gold Room Chairpersons: Hideki Taguchi and Jeffrey L. Brodsky
13:10 – 13:40 Molecular Origami: Protein folding and misfolding in health, aging and disease Judith Frydman - Stanford University
13:40 – 14:10 The UFM1 cycle in cellular proteostasis Ron Kopito - Stanford University
14:10 – 14:35 Molecular basis and physiological function of the CAT tailing in mammalian RQC. Toshifumi Inada - The University of Tokyo
14:35 – 15:00 Precise identification of dark proteins and their functional roles Akinobu Matsumoto - Nagoya University
15:00 – 15:20 A comprehensive exploration of translational responses during stresses in yeast Elie Teyssonniere - RIKEN
15:20–15:40
Coffee Break Venue: Foyer in front of the Main Hall
15:40-17:20
Session 2: Protein Quality Control – Chaperones and Folding Focusing on chaperone-mediated protein folding, quality control, and structural formation processes.
Venue: Gold Room Chairpersons: Judith Frydman and Toshifumi Inada
15:40 – 16:10 Mechanisms of co-translational folding and assembly of proteins Bernd Bukau - Heidelberg University
16:10 – 16:35 Nascent chain tracking to investigate proteostasis events in live cells. Hideki Taguchi - Institute of Science Tokyo
16:35 – 17:00 NMR Investigation of Chaperone-Mediated Protein Folding at Residue-Resolution Tomohide Saio - Tokushima University
17:00 – 17:20 Maintaining ER homeostasis is essential for brain function through cholesterol biosynthesis Hideki Nishitoh - University of Miyazaki
Day 2 – August 27 (Wednesday)
9:30–12:10
Session 3: Protein Degradation – Proteasome and Autophagy Focusing on degradation pathways, proteasome function, and autophagy.
Venue: Gold Room Chairpersons: Ronald Melki and Yukio Fujiki
9:30 – 10:00 Mechanisms of ER-associated protein degradation Pedro Carvalho - University of Oxford
10:00 – 10:25 Molecular mechanism of ER stress-dependent co-translational protein degradation Hisae Kadowaki - University of Miyazaki
10:25 – 10:50 Mechanism of autophagy initiation by phase separation Yuko Fujioka - Hokkaido University
10:50 – 11:05 Short Break
11:05 – 11:30 Autophagy; The Guardian Of Cells Against Diseases And Aging Tamotsu Yoshimori - The University of Osaka
11:30 – 11:50 Branched Ubiquitin Chains as Regulators of Proteostasis Fumiaki Ohtake - Hoshi University
11:50 – 12:10 HRD1 assembles into a nuclear pore-like nanocluster mesh that facilitates retrotranslocation of ER proteins Keisuke Mochida - Institute of Science Tokyo
12:10–13:30
Lunch Venue: Prince Hall
13:30–15:10
Session 4: Post-translational Modifications and Functional Diversity of Proteins Exploring functional impacts of palmitoylation, phosphorylation, ubiquitination, and other modifications.
Venue: Gold Room Chairpersons: Ron Kopito and Taroh Kinoshita
13:30 – 14:00 Functional specialisation of the human KDEL Receptors Roberto Sitia - Vita-Salute San Raffaele Universi-ty
14:00 – 14:25 Toward Finding a Cure for NGLY1 Deficiency Tadashi Suzuki - RIKEN
14:25 – 14:50 Toward Deciphering the Blueprint of Protein Glycosylation: From Molecular Dynamics to the Sub-Golgi Landscape Koichi Kato - National Institutes of Natural Sciences
14:50 – 15:10 A novel pathway enhancing protein disaggregase assembly promotes cellular fitness in primates Nadinath Nillegoda - Keio University
15:10–15:30
Coffee Break
Venue: Foyer in front of the Gold Room
15:30–17:10
Session 5: Emerging Technologies and the Future of Protein Research New possibilities in protein science enabled by advanced technologies. Venue: Gold Room Chairpersons: Bernd Bukau and Motomasa Tanaka
15:30 – 15:55 Sequence grammar and dynamics of subcellular translation revealed by APEX-Ribo-Seq Shintaro Iwasaki - RIKEN
15:55 – 16:20 PLOM-CON analysis: Image-based covariation network method to decode dynamic cellular processes Fumi Kano - Institute of Science Tokyo
16:20 – 16:50 Beyond the Helix: Unprecedented Features of the Filovirus Nucleocapsid Revealed by in situ Cryo-Electron Tomography Reika Watanabe - La Jolla Institute for Immunology
16:50 – 17:10 Inhibition of the aggregation of TDP-43 and its C-terminal fragments by chaperone RNA Akira Kitamura - Hokkaido University
17:10 – 17:15
Information – from Kyoto University Takayuki Homma
17:30–19:10
Poster Session Venue: Royal Room
Odd-numbered posters : 17:30–18:20
Even-numbered posters: 18:20–19:10
Day 3 – August 28 (Thursday)
9:00–10:45
Session 6: Stress Responses and Cellular Adaptation Discussing ISR, UPR, and physiological/pathological roles of protein aggregation.
Venue: Gold Room Chairpersons: Roberto Sitia and Tomohide Saio
9:00 – 9:30 DNAJB6: guardian of protein phase transitions and facilitator of aggregate disposal Harm H. Kampinga - University Medical Center Groningen
9:30 – 9:55 A Motor Neuron Disease-associated Mutation Produces Non-glycosylated Seipin that Induces ER Stress and Apoptosis by Inactivating SERCA2b Kazutoshi Mori - Kyoto University
9:55 – 10:25 Dynamic Regulation of the Proteasome by ECPS-1/Ecm29 Nicolas Lehrbach - Fred Hutchinson Cancer Center
10:25 – 10:45 Controlling Cancer Malignancy through Cell–Cell Adhesion Dynamics Yukako Oda - Kyoto University
10:45–11:05
Coffee Break Venue: Foyer in front of the Main Hall
11:05–13:15
Session 7: Organellostasis – Maintaining Intracellular Homeostasis Exploring inter-organelle coordination and roles of protein transport.
Venue: Gold Room Chairpersons: Harm H. Kampinga and Tadashi Suzuki
11:05 – 11:35 The identification of rare genetic variants linked to protein conformational disease and quality control Jeffrey L. Brodsky - University of Pittsburgh
11:35 – 12:00 "ERAD body" as a novel platform for endoplasmic reticulum protein quality control Ryo Ushioda - Kyoto Sangyo University
12:00 – 12:25 Crosstalk between metallostasis and proteostasis at the ER-Golgi interface Kenji Inaba - Kyushu University
12:25 – 12:50 Autophagy-Mediated Quality Control and Functional Recovery in the Nervous System Noboru Mizushima - The University of Tokyo
12:50 – 13:15 Peroxisome homeostasis: A paradigm shift of catalase research Yukio Fujiki - Kyushu University
13:15–
Symposium Commemorative Photo
13:25–17:30
Lunch & Excursion
17:30–18:30
Session 8: Special Lecture
Venue: Gold Room Chairpersons: Kaz Nagata
Heat Shock to Proteostasis Richard I. Morimoto - Northwestern University
18:30–
Reception & Poster award Ceremony Venue: Royal Room
Day 4 – August 29 (Friday)
10:00–11:40
Session 9: Pathogenic Protein Aggregation and Related Diseases Insights into diseases caused by aggregation-prone proteins, including amyloidosis and neurodegenerative disorders.
Venue: Gold Room Chairpersons: Nicolas Lehrbach and Kenji Inaba
10:00 – 10:30 Alpha-synuclein aggregates polymorphism and the molecular basis of diverse synucleinopathies Ronald Melki - University Paris-Saclay
10:30 – 10:55 Deciphering prion strains by in vitro-generated amyloid fibrils Motomasa Tanaka - RIKEN
10:55 – 11:20 Molecular mechanisms of Neurodegeneration induced by RNA G-quadruplexes Yasushi Yabuki - Kumamoto University
11:20 – 11:40 The DYT6 dystonia causative protein THAP1 is responsible for proteasome activity via PSMB5 transcriptional regulation Jun Hamazaki - University of Tokyo
